Team McCallum

R&D for Lifetime of Life

Nerve cell decay halted.

Nerve cell degeneration occurs in neurodegenerative diseases like Alzheimer’s, motor neurone disease, mutiple sclerosis, glaucoma and as part of the normal process of ageing.

Dr Jon Gilley and Dr Michael Coleman at the BBSRC (Biotechnology and Biological Sciences Research Council) have found a protein, called Nmnat2, without which axons (an essential part of healthy nerve cells) quickly degenerate, even if other nutrients are present. So it is like the equivalent of oxygen to human survival.

Adding external Nmnat2 was found to protect injured nerve cells, suggesting a possible treatment route for neurodegenerative diseases.

The full report is available for free in PLoS Biology.


January 31, 2010 - Posted by | Aging, Alzheimer's, Brain, Glaucoma, Health, Jon Gilley, Michael Coleman, Motor neurone disease, Multiple sclerosis, Nmnat2

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