Team McCallum

R&D for Lifetime of Life

Gene variant in young irregular heartbeat.

Another genetic variant in lone atrial fibrillation (irregular heart rhythm) has been reported by Patrick Ellinor, Stefan Kääb and others in Nature Genetics.

The team investigated lone atrial fibrillation (lone AF), a form of irregular heartbeat that occurs in younger people (before 65), has increased chance of family history, and where there is no other evidence of heart defect.

While other chromosomes are involved in atrial fibrillation, several studies were used to link lone AF to chromosome 1q21 and a part called rs13376333. This is a part of DNA that does not code for proteins but leads to KCNN3, which does encode a potassium channel protein that appears to be involved in the heartbeat process.

The authors noted further studies will be required to evaluate KCNN3 as a treatment target.

Click here for catheter ablation, a simple medical procedure for atrial fibrillation.


February 22, 2010 - Posted by | Ablation, Atrial fibrillation, Genetics, Patrick Ellinor, Stefan Kääb

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