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R&D for Lifetime of Life

Avandia row rumbles on.

The British Medical Journal has published a review of studies and articles that commented on rosiglitazone (Avandia) and risk of heart attacks in patients using the drug to treat diabetes. The review found those commenting favourably on Avandia were much more likely to have a financial conflict of interest than those commenting negatively.

In February, the US Food and Drug Administration said it would hold a public meeting in July to consider Avandia. This came after the New York Times released FDA internal documents that appeared to show Avandia is riskier than Actos. TeamMcCallum covered this here.

In the BMJ, the reviewers used a test of direct financial interest in rosiglitazone or general financial interest in drugs to counter hyperglycaemia.

Corresponding author Mohammad Hassan Murad, and 3 others from the Mayo Clinic, concluded “Disclosure rates for financial conflicts of interest were unexpectedly low, and there was a clear and strong link between the orientation of authors’ expressed views on the rosiglitazone controversy and their financial conflicts of interest with pharmaceutical companies” and that there is a need for better disclosure.

The BMJ review is here.

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March 20, 2010 - Posted by | Actos, Avandia, Cardiovascular Disease, Diabetes, Health, Mohammad Hassan Murad, Pioglitazone, Rosiglitazone, Science

1 Comment »

  1. […] The British Medical Journal has published a review of studies and articles that commented on rosiglitazone (Avandia) and risk of heart attacks in patients using the drug to treat diabetes. The review found those commenting favourably on … Read the original: Avandia row rumbles on. « Team McCallum […]

    Pingback by Avandia row rumbles on. « Team McCallum | FDA Warnings on popular drugs! | March 20, 2010 | Reply


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