Team McCallum

R&D for Lifetime of Life

Biomarker breakthrough in osteoarthritis?

Dr Guangju Zhai used a device that measures 163 chemical signals simultaneously from a single drop of human blood to search for markers associated with knee arthritis.

A comparison of those with osteoarthritis and those without allowed the team to identify two ratios that link with the disease.

These happen to be valine to histidine and xleucine to histidine – types of amino acids.

Getting an easy test that identifies onset of osteoarthritis would represent a real breakthrough in treatment, but more needs to be done.

According to Dr Zhai “The two novel metabolic biomarkers found through our study could indicate increased cartilage breakdown and we now want to study these mechanisms in more detail.”


April 23, 2010 - Posted by | Guangju Zhai, Osteoarthritis, Science

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