Team McCallum

R&D for Lifetime of Life

New gene found in family cancer.

Professor Alfons Meindl and team have added RAD51C to the list of genes involved in the inherited version of breast and ovarian cancer.

15 years ago the discovery of BRCA1 and BRCA2 was a breakthrough in the prediction and treatment of such cancers.

Like BRCA1/2, RAD51C is also normally a tumour suppressor, responsible for repairing DNA in cells.

According to the US National Institutes of Health, BRCA1/2 account for around 5-10% of breast cancers and 10-15% of ovarian cancers. The NIH lists a further 8 genes implicated in inherited breast and ovarian cancer, with BRCA1/2 and RAD51C bringing the total to 11. The NIH also points out the availability of genetic testing in families with mutiple members who have, or have had, these cancers.

According to Professor Meindl “The now known genes that predispose women to breast and/or ovarian cancer only explain 60% of the high-risk families. We are also optimistic that in the future the individual breast cancer risks for the majority of women can be determined. These risk predictions will allow the offering of tailored prevention.”


April 24, 2010 - Posted by | Alfons Meindl, Breast cancer, Cancer, DNA test, Genetics, NIH - National Institutes of Health, RAD51C

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