Team McCallum

R&D for Lifetime of Life

Environment v diabetes.

Genome-wide association studies (GWAS) are standard ways to seach through all the literature on a given condition and find which genetic conditions relate to it.

Prof Atul J Butte has published the first EWAS (environment-wide association study). In this case, type 2 diabetes was studied.

The team found the following environmental factors increased the risk of getting type 2 diabetes
– exposure to heptachlor epoxide. (This results when bacteria and animals break down heptachlor, which was used in a number of pesticides until banned in 1986)
– gamma-tocopherol. This is one of 8 compounds that may be called vitamin E. According to Wikipedia, alpha-tocopherol is the main source found in supplements, and in the European diet, while gamma-tocopherol is the most common form in the American diet.
– PCBs.

A protective factor was beta-carotene, the precursor to vitamin A, found in carrots etc.


May 26, 2010 - Posted by | Atul J Butte, Diabetes, Diet, Health, Vitamin A, Vitamin E

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