Team McCallum

R&D for Lifetime of Life

Gender, stress, depression, PTSD.

Dr Debra A Bangasser and team looked at what happened in the brains of rats subjected to stress, and found 2 key differences between males and females.

The findings relate to a particular brain neuron receptor, one handling CRF. CRF is a hormone that organises stress responses in mammals.

In females, the receptors bound tightly to CRF at low levels, whereas in males this did not happen. In plain English, females were more affected by low levels of stress.

When high levels of stress happened, males adjusted to this by reducing the number of receptors, making them less sensitive. In females, this did not happen, leaving them open to full impact.

The combination may explain why women are twice as likely as men to be affected by stress-related conditions, including depression and PTSD.

The results also suggest that drug treatment should take into account these gender differences that are occurring in the brain.


June 15, 2010 - Posted by | Brain, Debra A Bangasser, Depression, Gender, Medicine/Treatment, PTSD

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