Team McCallum

R&D for Lifetime of Life

Cancer drug for autoimmune?

Prof Shinichi Sato has found that the way that anti-cancer drug bortezomib (Velcade) works suggests it may be successful in fighting autoimmune and inflammatory diseases (arthritis, MS, IBD, lupus).

T cells are white blood cells that get tailored to attack specific invaders, but in autoimmune diseases start to attack the body’s own tissues.

In simple terms, the drug causes active and proliferating T cells to die (those carrying out the self-attack), while leaving other T cells unharmed (so the immune system still works).

The research was in mice so it may not work as well as in humans, but the mechanism opens up another potential cure route in autoimmune/inflammatory diseases.

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July 1, 2010 - Posted by | Arthritis, IBD, Multiple sclerosis, Shinichi Sato

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