Team McCallum

R&D for Lifetime of Life

Diabetes drugs v fractures.

Dr William H Herman has published a study of the association between popular drugs for diabetes 2 and the risk of bone fractures.

The team looked at nearly 800 cases of fractures in patients with diabetes and compared against over 2,500 diabetic patients without fractures.

The drugs checked were both in the thiazolidinedione class (TZDs) – pioglitazone (Actos) and rosiglitazone (Avandia).

In men who took both loop diuretics (water tablets) and TZDs, there was an increased risk of fractures. This risk did NOT show up in men who were taking TZDs only.

In postmenopausal women, taking TZDs was associated with an increased risk of fractures, and in this case, the risk was dose-dependent.

The results for Actos and Avandia were similar, suggesting this is a feature of TZDs.

According to Dr Herman “Physicians should be aware of this risk and weigh the benefits and risks of therapy when they initially prescribe or renew prescriptions for TZDs.”

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July 29, 2010 - Posted by | Actos, Avandia, Diabetes, Gender, Health, Pioglitazone, Rosiglitazone, Success

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