Team McCallum

R&D for Lifetime of Life

Diet drug Contrave?

Prof Frank L Greenway has reported on the findings of the largest clinical trial of Contrave in The Lancet today.

It appears to work – but ….

Contrave is a special mix of two existing drugs – naltrexone and buprion.

The combination works in two ways – it cuts appetite – and it works in the brain’s reward centre to reduce impulse eating.

The dropout rate in the 56 week trial was 50%. This was claimed to be normal – around 30% of those on Contrave had nausea while the placebo controls typically gave up due to poor weight loss.

Those completing the trial lost around 8% of the bodyweight.

In an editorial on this, Dr Arne Astrup was cautious. Both component drugs were known to increase blood pressure, and the trial results did not report an improvement in blood pressure or ‘good’ cholesterol.

Contrave should be considered for approval by the US Food and Drugs Administration in October.


July 31, 2010 - Posted by | Arne Astrup, Cholesterol, Contrave, Frank L Greenway, High blood pressure, Obesity, Weight management

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