Team McCallum

R&D for Lifetime of Life

DBS Alzheimer’s trial recruiting.

A pilot study at the Toronto Western Hospital on deep brain stimulation (DBS) in Alzheimer’s has been reported in the Annals of Neurology.

Dr Andres M Lozano had found, by accident, that DBS  triggered vivid memories and lasting memory improvement in a patient being treated for an unrelated condition.

The small pilot on 6 people with Alzheimer’s assessed safety and attempted to explain why DBS might work. One finding was that with DBS there was a significant reversal of impaired glucose metabolism in 2 areas of the brain.

On a standard test for cognitive ability, the Mini-Mental State Examination, 2 patients improved and 2 remained steady over the course of a year, rather than following the normal pattern of decline in Alzheimer’s.

The team is now looking to recruit a further 50 patients for a stage 2 trial. Click here for details.


August 6, 2010 - Posted by | Alzheimer's, Andres M Lozano, Brain, DBS - deep brain stimulation, Memory, MMSE cognitive test, Success

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