Team McCallum

R&D for Lifetime of Life

Herbal anti-cancer drug.

Prof Yung-Chi Cheng has published the results of a study into why PHY906 reduces the side effects of anti-cancer drug irinotecan (CPT11) in the current issue of Science Translational Medicine.

But the interesting story comes from an interview with Cheng, also published in the magazine.

PHY906 is based on a traditional Chinese herbal remedy which is used to treat gastrointestinal disorders and diarrhea. Cheng’s team wanted to see if that applied in cancer chemotherapy, but first they had to be sure the herbs would not block irinotecan.

In mice, they found that it enhanced the anti-tumour action. Plus it cut the gastric side-effects.

Further, PHY906 appears to have a degree of anti-cancer impact when used on its own (again, in mice).

Not only does it appear to boost the anti-cancer drug effect with irinotecan in colorectal cancer, it appears to boost capecitabine in liver cancer, and gemcitabine in pancreatic cancer.

Early trials in humans, to check that it reduces side effects, are at various stages.

PHY906 is a patented mix based on Huang Qin Tang, and the trials are part of the process of getting PHY906 approved as a prescription medicine by the FDA.

The team has devloped a way to test the 4 herb ingredients are in the right proportions, time after time. As part of this, they found that Huang Qin Tang made up by Chinese herbalists produces a 65% to 90% match to PHY906.

According to Cheng, Huang Qin Tang is first cooked then you drink the extract.

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August 19, 2010 - Posted by | Cancer, Huang Qin Tang, Yung-chi Cheng

1 Comment »

  1. Lung cancer, the leading cancer killer in both men and women, is notoriously difficult to treat. Herb Extract

    Comment by Herb Extract | August 19, 2010 | Reply


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