Team McCallum

R&D for Lifetime of Life

Diabetes and Alzheimer’s.

Dr Kensuke Sasaki found that insulin resistance and high blood glucose levels found 10 to 15 years before death was linked at death to higher levels of the brain plaque found in Alzheimer’s but not to the protein tangles associated with the disease.

135 Japanese men and women were autopsied, providing the evidence of the beta-amyloid plaque. Between 10 and 15 years earlier, when they were deemed free of dementia, they undertook tests revealing blood glucose and insulin levels, amongst other things.

While 16% had been diagnosed with Alzheimer’s before death, 65% had the characteristic plaques of Alzheimer’s.

Compared to those with normal sugar levels who did not carry the APOE gene variant known to increase risk of Alzheimer’s – high glucose alone raised the risk by a half – the risky APOE variant on it’s own raised the risk by nearly 20 times – and risky APOE plus high glucose increased risk nearly 40 times.

Insulin resistance raised the risk by about a half, but did not appear to interact with APOE.

The authors concluded “Adequate control of diabetes might contribute to a strategy for the prevention of Alzheimer’s disease.”

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August 28, 2010 - Posted by | Aging, Alzheimer's, APOE, Diabetes, Health, Kensuke Sasaki, Success

3 Comments »

  1. […] Diabetes and Alzheimer’s. (via Team McCallum) Dr Kensuke Sasaki found that insulin resistance and high blood glucose levels found 10 to 15 years before death was linked at death to higher levels of the brain plaque found in Alzheimer’s but not to the protein tangles associated with the disease. 135 Japanese men and women were autopsied, providing the evidence of the beta-amyloid plaque. Between 10 and 15 years earlier, when they were deemed free of dementia, they undertook tests revealing bl … Read More […]

    Pingback by Diabetes and Alzheimer’s. (via Team McCallum) « Momma Donna | August 29, 2010 | Reply

  2. Diabetes and Alzheimer?s….

    I found your entry interesting do I’ve added a Trackback to it on my weblog :)…

    Trackback by Mental Disorders 101 | August 30, 2010 | Reply

  3. […] Posted By admin on August 28, 2010 Tweettweetmeme_style = 'compact';tweetmeme_url='http://mommadonna.roadproservices.com/2010/08/28/diabetes-and-alzheimers-via-team-mccallum/'; Dr Kensuke Sasaki found that insulin resistance and high blood glucose levels found 10 to 15 years before death was linked at death to higher levels of the brain plaque found in Alzheimer’s but not to the protein tangles associated with the disease. 135 Japanese men and women were autopsied, providing the evidence of the beta-amyloid plaque. Between 10 and 15 years earlier, when they were deemed free of dementia, they undertook tests revealing bl … Read More […]

    Pingback by Momma Donna » Diabetes and Alzheimer’s. (via Team McCallum) | October 4, 2010 | Reply


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