Team McCallum

R&D for Lifetime of Life

Genes – weight – exercise.

Dr Ruth Loos has looked at the effect of genetics and exercise on weight in a large study of people in Norfolk.

20,400 were followed for 3 and a half years. Various measurements including body mass index (BMI) and physical activity levels were taken at the start.

Each person had their genetics sequenced for 12 known ‘fat’ genes, with each of these scoring no copies, 1 copy or 2 copies, giving a 0-24 total.

Nearly 12,000 of these people also had their BMI measured at the end, so changes could be tracked over time.

For a person of 1m 70cm (5ft 7″), each ‘fat’ copy they had added 454g (1lb). For the inactive, this went up to 592g, while for the active this was 379g, a saving of about 36%.

Over the duration of the study, the inactive group gained weight, while the active group lost as much weight as the inactive group gained.

In the study, inactive was a sedentary job combined with no recreational activity. Active was anything equivalent to at least an hour a day of recreational activity or a heavy manual job. Intermediate levels produced intermediate results.

Prof Theodore Garland Jr finds out that activity/exercise has a strong genetic basis!


September 1, 2010 - Posted by | Activity, BMI - body mass index, FTO rs9939609, Genetics, Obesity, Ruth Loos, Success, Theodore Garland Jr, Weight management

1 Comment »

  1. […] By sheer coincidence, on the same day that Dr Ruth Loos publishes on the impact of exercise on the genetic component of weight, Prof Theodore Garland Jr finds that NOT being a couch potato has a high genetic […]

    Pingback by Exercise genes. « Team McCallum | September 1, 2010 | Reply

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