Team McCallum

R&D for Lifetime of Life

Statins v arthritis.

Dr Gabriel Chodick found that statins cut the risk of contracting rheumatoid arthritis significantly, but the impact on osteoarthritis was less clear.

The study looked at people in Israel who had neither condition at the start, and followed them for around 10 years. Roughly 200,000 people were eligible for the rheumatoid arthritis study, with another 200,000 in the osteoarthritis study.

The research demonstrated a connection between persistent use of statins and a reduced risk of rheumatoid arthritis, cutting this by about 40%.

This did not appear to be caused by lowering cholesterol. The researchers speculated that reduced levels of inflammation as a result of lower levels of CRP (C-reactive protein) made sense. With less inflammation there would be less need for an immune system response, the core of rheumatoid arthritis.

The impact on osteoarthritis was weaker, in keeping with the idea that osteoarthritis doesn’t have an autoimmune system basis.

Statins protective benefits against rheumatoid arthritis were more marked in younger patients and in those on persistent treatment to lower LDL cholesterol by the most (40% or more).


September 8, 2010 - Posted by | Arthritis, Cholesterol, Gabriel Chodick, Health, Osteoarthritis, Statin, Success

1 Comment »

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