Team McCallum

R&D for Lifetime of Life

Anti-aging supplements.

A study in Italy using mice has found that 3 essential amino acids increase lifespan by an average of 12%.

Dr Enzo Nisoli compared mice fed supplements of branched-chain amino acids (leucine, isoleucine and valine) to others without this to find out why the animals lived longer. Previous studies have shown benefits in a range of different life forms, including humans.

Essential amino acids are those we need to get from food as human bodies cannot form them from other substances. The three branched-chain amino acids are strongly linked to building muscle.

Dr Nisoli found the supplements worked by turning on energy production in muscle cells and turning up the anti-oxidation in the cells, giving greater protection against cell damage. These effects worked to counter the natural decline of muscle function in older mice, restoring them to close to their prime condition.

The improvements were to heart and skeletal muscles. There was no change in fat cells or in liver function.

The supplements have been tested before in animals younger than their prime and at this time had no impact. The Italian study makes it clear that it is working by prevention of natural decline.

The three branched-chain amino acids (leucine, isoleucine and valine) are widely available from supplement suppliers at inexpensive prices.

Dr Nisoli’s paper compared, in some detail, the effects of these branched-chain amino acids to other anti-aging methods, including calorie-restriction, moderate physical exercise, and anti-oxidants including vitamin C, vitamin E and resveratrol. To celebrate the blog’s 40,000th view, a special on this topic will appear shortly.


October 7, 2010 - Posted by | Activity, Aging, Amino acids, Diet, Enzo Nisoli, Exercise, Health, Resveratrol, Success, Vitamin C - ascorbic acid, Vitamin E

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