Team McCallum

R&D for Lifetime of Life

Combo HRT bad in breast cancer.

A study of the Women’s Health Initiative, (12,800 US post-menopausal) women followed for an average of 11 years), found that hormone replacement therapy (HRT) consisting of a combination of estrogen plus progestin gave a higher risk of breast cancer, death from breast cancer and death from all causes.

Initially, the women were randomly assigned to either estrogen plus progestin or to a placebo. The study began in 1993 and was planned to run until 2005. It was anticipated that it would find that combined HRT would cut the risk of heart disease. 

However, the trial was stopped early in 2002 when a preliminary analysis of results showed estrogen/progestin increased the risk of heart disease, stroke and breast cancer.

The current extension check was because it was believed that beast cancer after combined HRT would be less advanced and so have a lower risk of death. But on checking, the research team found the opposite as HRT interfered with the detection of breast cancer, so it was usually more advanced and so more deadly.

The report appears in the Journal of the American Medical Association.


October 21, 2010 - Posted by | Breast cancer, CVD - cardiovascular disease, Health, HRT, Stroke, Success

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