Team McCallum

R&D for Lifetime of Life

Aspirin cuts superbug.

Dr Rabin Rahmani has told the annual meeting of the American College of Gastroenterology that aspirin reduces the rate of infections of superbug Clostridium difficile (C. diff) and that a higher dose provides greater protection.

Dr Rahmani looked at the records of 30,000 hospitalised patients and found that aspirin in general (81 mg or 325 mg) cut the risk of C. diff diarrhoea by 40%, while a 325 mg/day dose cut the risk by 52%.

Aspirin is thought to work against C. diff in two ways. First, it cuts the expression of an inflammatory substance called COX-2. Other non-steroidal anti-inflammatory drugs (NSAIDS) also inhibit COX-2, so they should confer some protection, although this was not investigated by Dr Rahmani.

Secondly, C. diff requires an acidic environment and aspirin makes the colon less acidic.

The study has yet to be published in a peer-reviewed journal.

Advertisements

October 23, 2010 - Posted by | Aspirin, C. diff - Clostridium difficile, Health, NSAID, Success

No comments yet.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: