Team McCallum

R&D for Lifetime of Life

Aspirin cuts superbug.

Dr Rabin Rahmani has told the annual meeting of the American College of Gastroenterology that aspirin reduces the rate of infections of superbug Clostridium difficile (C. diff) and that a higher dose provides greater protection.

Dr Rahmani looked at the records of 30,000 hospitalised patients and found that aspirin in general (81 mg or 325 mg) cut the risk of C. diff diarrhoea by 40%, while a 325 mg/day dose cut the risk by 52%.

Aspirin is thought to work against C. diff in two ways. First, it cuts the expression of an inflammatory substance called COX-2. Other non-steroidal anti-inflammatory drugs (NSAIDS) also inhibit COX-2, so they should confer some protection, although this was not investigated by Dr Rahmani.

Secondly, C. diff requires an acidic environment and aspirin makes the colon less acidic.

The study has yet to be published in a peer-reviewed journal.


October 23, 2010 - Posted by | Aspirin, C. diff - Clostridium difficile, Health, NSAID, Success

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