Team McCallum

R&D for Lifetime of Life

Preventing Alzheimer’s?

Earlier in 2010 TeamMcCallum published research showing that beetroot juice lowered high blood pressure. The mechanism was that beetroot is rich in nitrate, bacteria on the tongue convert this to nitrite, which in turn gets converted to nitric oxide. The nitric oxide dilates blood vessels and so lowers blood pressure.

Now Dr Zvonimir S Katusic and team from the Mayo Clinic in Rochester, Minnesota, have researched the apparent risk link between cardiovascular disease (CVD) and Alzheimer’s. The study involved looking at the function of the lining of blood vessels (endothelium) in the brain.

First, the team inhibited the generation of nitric oxide by the vessels. This triggered a series of events that led to increased production of the amyloid precursor protein (APP), and an enzyme that normally cuts APP up so it can be disposed of. This increase in production/disposal led to an increase in the production of beta-amyloid plaque, one of the two major things seen in Alzheimer’s.

They checked the result in mice bred to be deficient in production of nitric oxide. These mice are insulin-resistant and have high blood pressure. The results were the same – more APP, more enzyme to chop it up, and more beta-amyloid plaque production.

According to one of the team “On the cardiovascular side we’ve known for some time that preservation of healthy endothelium is critical to prevent major cardiovascular events. Now it seems this may have important implications for cognitive impairment.”

Risk factors for CVD (high cholesterol, diabetes, high blood pressure, smoking, sedentary lifestyle and aging) have all been associated with inability of the endothelium to produce enough nitric oxide. Now they are linked by this research to Alzheimer’s.

This explains the protective effect of, say, exercise. And beetroot juice too!

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December 4, 2010 - Posted by | Aging, Alzheimer's, Cholesterol, Cognitive decline, CVD - cardiovascular disease, Exercise, High blood pressure, Obesity, Smoking, Success

1 Comment »

  1. Oh, you missed the protective effect of, let say, ethanol, caffeine, calorie restriction. And talking about cholesterol I hope you mean LDL-C, not any cholesterol. Nice blog.

    Comment by Ilya B | December 5, 2010 | Reply


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